Organocatalytic asymmetric chlorinative dearomatization of naphthols
|
| |
| Authors: | Qin Yin Shou-Guo Wang Xiao-Wei Liang De-Wei Gao Jun Zheng Shu-Li You |
| |
| Institution: | a State Key Laboratory of Organometallic Chemistry , Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences , 345 Lingling Lu , Shanghai 200032 , China . Email: ; Fax: +86-21-5492-5087 |
| |
| Abstract: | An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation. |
| |
| Keywords: | |
|
|
