Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties. |
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| Authors: | G A Pinna G Loriga G Murineddu G Grella M Mura L Vargiu C Murgioni P La Colla |
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| Affiliation: | Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Sardinia, Italy. pinlab@uniss.it |
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| Abstract: | In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range. |
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