Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives |
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| Authors: | René Pemha Dieudonné Emmanuel Pegnyemb Paul Mosset |
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| Affiliation: | 1. Université de Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Rennes, France;2. AGIR, EA 4294, UFR of Pharmacy, Jules Verne University of Picardie, Amiens, France;3. pemharene@gmail.com;5. Département de Chimie Organique, Faculté des Sciences, Université de Yaoundé I, Yaoundé, Cameroun;6. Université de Rennes, CNRS, ISCR, UMR 6226, Rennes, France |
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| Abstract: | AbstractResistance to the existing drugs and increasing numbers of diseases result in identifying new drug candidates with new forms of activity. As marine organisms are well known to provide a wide range of original compounds, Herein, we report the synthesis of new non-natural brominated, iodinated and chlorinated-substituted 1-O-alkylglycerols 5–7, analogs of a prominent 1-O-alkylglycerol (AKG) of the natural shark liver oil (SLO) mixture, namely the AKGs 18:1, n-9. |
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| Keywords: | Alkylglycerol (AKG) fatty acids halogenated compounds lipids marine natural products |
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