The 1,3-dipolar cycloaddition of adamantine-derived nitrones with maleimides |
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Authors: | Alexander P. Molchanov Valentina M. Lukina Mariia M. Efremova Anna A. Muryleva Alexander V. Slita Vladimir V. Zarubaev |
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Affiliation: | 1. Institute of Chemistry Saint Petersburg State University, St. Petersburg, Russian Federation;2. a.molchanov@spbu.ru;4. Saint Petersburg Pasteur Institute, St. Petersburg, Russian Federation |
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Abstract: | AbstractAdamantane-derived aldo- and ketonitrones react with maleimides giving corresponding isoxazolidines. In the case of aldonitrones reactions proceed giving the diastereomeric mixtures. The ratio of isomers is changing during the reaction process due to the reversibility of the cycloaddition reaction. The cytotoxic and virus-inhibiting activity against influenza virus was investigated for selected adducts. |
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Keywords: | Adamantane antiviral activity cycloaddition isoxazolidines nitrones |
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