A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

Authors:	Yong-Qi Wu Hai-Jia Lu Wen-Ting Zhao Hong-Yi Zhao Zi-Yun Lin

Affiliation:	Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Abstract:	Abstract A convenient, rapid H₂SO₄-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H₂SO₄ using N-chlorosuccinimide and N-iodosuccinimide, respectively.

Keywords:	N-Bromosuccinimide phenol analogs regioselective monobromination salicylic acid derivatives sulfuric acid