Facile synthesis and anti-proliferative activity evaluation of quinoxaline derivatives |
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| Authors: | Jin Lin Panpan Wang Zemin Zhang Guozhen Xue Daijun Zha Jian Wang |
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| Affiliation: | 1. Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, China;2. School of Pharmacy, Fujian Medical University, Fuzhou, China |
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| Abstract: | AbstractA series of “drug-like” compounds based on quinoxaline scaffold with arylsulfonyl hydrazinyl, arylformyl hydrazinyl or arylsulfonyl groups at C-2 and aryloxy groups at C-3, were synthesized in 4 or 5 steps involving cyclization, chlorination and coupling reactions. Cellular anti-proliferative activities of these quinoxaline derivatives in vitro were determined, which revealed that the inhibitory potency and selectivity of 6f was comparable to that of the positive control. |
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| Keywords: | Arylformyl hydrazinyl arylsulfonyl 2-arylsulfonyl hydrazinyl-3-aryloxy quinoxaline antitumor activity synthesis |
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