Transition-metal-free mono- or dinitration of protected anilines |
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| Authors: | Enrui Dai Yongrui Dong Rui Kong Guangzhang Liu Ying Dong Qiong Wu |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Kunming University, Kunming, China;2. College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China;3. Yunnan Engineering Technology Research Center for Plastic Films, Kunming, China |
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| Abstract: | AbstractAn amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity. |
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| Keywords: | Amide-assisted strategy anilides C???H functionalization divergent synthesis radical reaction |
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