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Rhodium-catalysed chemo- and regio-selective [3?+?2+2] cycloadditions of bis(methylenecyclopropanes) and alkynes: Synthesis of spirocyclic 5–7 condensed cycloheptenes |
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| Authors: | Bilash Kuila Priyanka Sharma Dinesh Mahajan Prabhpreet Singh |
| Institution: | 1. Department of Chemical Sciences, I. K. Gujral Punjab Technical University, Kapurthala, India;2. Drug Discovery Research Center, Translational Health Science and Technology Institute, Faridabad, India;3. Department of Chemistry, Guru Nanak Dev University, Amritsar, India |
| Abstract: | AbstractRhodium-catalyzed intermolecular 3?+?2+2] cycloaddition reactions of bis(methylenecyclopropanes) with different alkynes are described. The rhodium-catalyzed 3?+?2+2] cycloadditions resulted in the formation of functionalized 5–7–3 spirocyclic carbocycles in moderate yields with excellent regio- and chemo-selectivity. |
| Keywords: | [3?+?2+2] Cycloadditions [Rh(COD)Cl]2 bis(methylenecyclopropanes) multicomponent reaction spirocyclic cycloheptenes |