Simple route to new oxadiazaboroles and oxadiazoles via amidoximes |
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| Authors: | Mihály V. Pilipecz Tamás R. Varga Péter Králl Zoltán Vincze Zoltán Mucsi Ruth Deme |
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| Affiliation: | 1. Department of Chemistry, University of Veterinary Medicine, Budapest, Hungary;2. Femtonics LTD, Budapest, Hungary;3. Department of Pharmaceutical Chemistry, Semmelweis University of Medicine, Budapest, Hungary |
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| Abstract: | AbstractThe novel push–pull alkene, the 2-(nitro-nitrosomethylene)-pyrrolidine with numerous aliphatic or aromatic amines as nucleophiles afforded amidoximes. Various substituted oxadiazaborole and oxadiazole derivatives were prepared starting from these amidoximes, widening the synthetic applicability of the push–pull alkenes. Acylation of the amidoximes was also examined. The mechanism of the amidoxime formation was investigated by computational methods. |
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| Keywords: | Amidoximes computational methods cyclization oxadiazoles oxadiazaboroles |
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