Design and chemical behavior of novel pyrimidine derivatives and their evaluation of cytotoxicity |
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Authors: | Alaa R. Sakr Mohamed G. Assy Youssra S. ELasaad |
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Affiliation: | 1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig City, EgyptAlaasakr81@yahoo.com;3. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig City, Egypt |
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Abstract: | AbstractDiphenyl-4-thioxo-1,4-dihydropyrimidin-5-yl)ethan-1-one 4 was obtained upon the reaction of (phenylamino)but-2-enethioyl)benzamide 3 with sodium hydroxide. The reactions of 4 with several active species such as benzaldehyde, urea, malononitrile, ethyl cyanoacetate, hydrazine, and carbon disulfide were studied. The antitumor activities of some selective compounds were examined against two cell lines: Mammalian cell lines: A-549 cells (human lung cancer cell line) and MRC-5 cells (normal human lung fibroblast cell line); some of the compounds were highly efficient; compound 13 has the most effective anticancer activity. |
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Keywords: | Enamine benzoyl isothiocyanate pyrimidine pyran antitumor assay |
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