Intramolecular benzyl protection delivery: a practical synthesis of DMDP and DGDP from D-fructose |
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| Authors: | García-Moreno M Isabel Aguilar Matilde Ortiz Mellet Carmen García Fernández José M |
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| Affiliation: | Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Spain. |
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| Abstract: | [reaction: see text] A two-step protection of 1,2-diols as the corresponding o-xylylene cyclic ethers, involving an intramolecular ring-closing O-benzylation reaction, has been developed to overcome the problems associated to regioselective benzylation reactions. The strategy has been applied to the high-yielding synthesis of the pyrrolidine glycosidase inhibitors DMDP and DGDP. |
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