| 灵长类中风模型的磁共振成像 |
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| 引用本文： | 张晓东. 灵长类中风模型的磁共振成像[J]. 波谱学杂志, 2010, 27(4): 548-561. DOI: 10.3969/j.issn.1000-4556.2010.04.006 |
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| 作者姓名： | 张晓东 |
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| 作者单位： | 1. Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30392, USA;2. Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30392, USA |
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| 基金项目： | A URC research grant from Emory University and Yerkes NIH/NCRR base grant (P51 RR000165). |
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| 摘 要： | 灵长类大脑在结构、生理、功能及神经学上与人类大脑非常相似. 因此，灵长类中风模型为研究大脑缺血的损伤机制和开发各种药物治疗方法提供了理想的动物模型. 该文介绍了近年来使用的各种灵长类中风模型，并总结了目前可用于该模型的各种磁共振成像（MRI）方法. 同时，还讨论了灵长类动物高分辩弥散张量成像（DTI）和磁共振灌注成像（PWI）的数据采集方法和心跳及呼吸引起的生理运动伪影的矫正方法. 这些方法改进了弥散一灌注失配（DWI－PWI MISMATCH）成像的精度和质量，有助于提高对脑缺血半暗带演化及其对药物治疗反应的精确评估，为更好地利用灵长类脑中风模型和当代磁共振成像技术进行中风机制研究和药物开发建立一个理想的研究平台.
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| 关 键 词： | 灵长类 中风模型 磁共振成像 脑中动脉缺血 弥散张量成像 磁共振灌注成像 生理运动伪影矫正 |
| 收稿时间： | 2010-09-14 |
Magnetic Resonance Imaging of Non-Human Primate Ischemic Stroke Models |
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| ZHANG Xiao-dong. Magnetic Resonance Imaging of Non-Human Primate Ischemic Stroke Models[J]. Chinese Journal of Magnetic Resonance, 2010, 27(4): 548-561. DOI: 10.3969/j.issn.1000-4556.2010.04.006 |
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| Authors: | ZHANG Xiao-dong |
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| Affiliation: | 1. Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30392, USA;;2. Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30392, USA |
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| Abstract: | As the non-human primate (NHP) brain is gyroencephalic, structurally and functionally similar to the human brain, NHP stroke models provide an ideal platform for investigating the mechanism of ischemic brain injury and developing therapeutical treatment.In this paper, various NHP ischemic stroke models studied recently are summarized.The imaging protocols available for quantitative MRI measurements of NHP stroke models are introduced.In addition, data acquisition and physiological motion correction of high-resolution diffusion tensor imaging and continuous arterial-spin-labeling(CASL) based perfusion imaging for NHP are illustrated and discussed.The article provides an overview of NHP stroke models and approach for implementing quantitative multi-parameter MRI evaluation to characterize stroke injury for therapy and drug discovery. |
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| Keywords: | non-human primate ischemic stroke model high-resolution MRI diffusion-perfusion mismatch physiological motion correction |
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