| 褪黑激素的合成与表征 |
| |
| 引用本文： | 杨建武,曹会兰. 褪黑激素的合成与表征[J]. 化学研究, 2003, 14(4): 42-44 |
| |
| 作者姓名： | 杨建武 曹会兰 |
| |
| 作者单位： | 1. 西北大学,应用化学研究所,陕西,西安,710068
2. 渭南师范学院,化学系,陕西,渭南,714000 |
| |
| 摘 要： | 以吲哚为起始原料,经4步反应合成了褪黑激素(MLT) 吲哚(1)在甲醇中羟基化得到5-羟基吲哚(2),(2)同2-氯乙胺在乙酸乙酯中进行胺乙基化反应得到5-羟基色胺(3),(3)与硫酸二甲酯在甲苯中对羟基进行醚化,得到5-甲氧基色胺(4),(4)经乙酰化得到产物MLT,收率80%
|
| 关 键 词： | 褪黑激素 吲哚 5-羟基吲哚 5-羟基色胺 5-甲氧基色胺 合成 |
| 文章编号： | 1008-1011(2003)04-0042-03 |
| 修稿时间： | 2003-04-22 |
Synthesis and Characterization of Melatonin |
| |
| YANG Jian-wu. Synthesis and Characterization of Melatonin[J]. Chemical Research, 2003, 14(4): 42-44 |
| |
| Authors: | YANG Jian-wu |
| |
| Affiliation: | YANG Jian-wu~ |
| |
| Abstract: | The title compound was prepared by a four-step reaction route with indole as a main starting material. Indole (1) was hydroxylated in methanol to give 5-hydroxyindole (2) in 71 % yield. Compound (2) reacted with 2-chloride ethylamine in ethyl acetate to give serotonin (3) in 73 % yield, and compound (3) reacted with dimethyl sulfate in toluene to give 5-methyoxytryptamine (4) in (78 %) yield, and compound (4) was acetylated to give the title compound MLT in 80 % yield. |
| |
| Keywords: | melatonin indole 5-hydroxyindole serotonin 5-methoxytryptamine synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
