甲酸铵Pd/C体系进行胺化反应的研究

介绍了一种用于羰基胺化的合成方法.该方法以酮为底物，HCOONH₄为氢源和氮源，Pd/C为催化剂，CH₃OH与H₂O为溶剂，对羰基进行还原胺化制得相应的胺.甲酸铵作为氢供体，具有廉价、易得、还原性能好等优点，Pd/C催化加氢可使反应在温和的条件下进行.该方法反应速度快、后处理方便、选择性好.最佳反应条件：常温常压、CH₃OH∶H₂O(V∶V)=9∶1、HCOONH₄∶原料∶Pd/C(M∶M∶M)=100∶10∶1.实验过程中，分别对2-金刚烷酮；5-氨基羟基-2-金刚烷酮；3-奎宁酮进行了胺化反应研究，获得较好的结果，产物均经¹H-NMR、GC-MS或MS确证结构.

Amination based on the system of ammonium formate-Pd/C

A method for the amination of compounds with carbonyl groups was described. The process was carried out by using ketones as substrates,ammonium formate as the source of hydrogen and nitrogen,Pd/C as catalyst and the mixture of methanol and water as solvent under normal temperature and pressure. Ammonium formate as hydro- gen supplier has the advantages of low cost,easy availability as well as excellent reducibility, while Pd/C as catalyst enables the reaction to take place under mild conditions. The process reacts quickly with convenient workup and high selectivity. The optimal reaction conditions were as follows：CH3OH ： H20（V： V） ：9： 1, HCOONH4：ketone：Pd/C（M ： M ： M）= 100 ： 10 ： 1. Here the amination of 2-adamantanone, 5-hydroxy-2-adam antanone and 3-quinin- eone were studied with satisfactory results. All products were eonfirmed by 1H-NMR,GC-MS or MS.