Synthesis of oxygen heterocycles by regioselective Heck reaction |
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Authors: | McConville Matthew Ruan Jiwu Blacker John Xiao Jianliang |
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Affiliation: | Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, UK. |
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Abstract: | The regioselective Heck arylation of unsaturated alcohols is utilized as the key step in a convenient one-pot procedure for the production of 2,2-disubstituted tetrahydrofurans and tetrahydropyrans. The arylation reaction is effected with a palladium-diphosphine catalyst alongside a hydrogen bond donor; this is followed by the introduction of a Br?nsted acid to the reaction mixture, affording the oxygen heterocycles in moderate yields. |
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