New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs |
| |
| Authors: | Placzek Andrew T Gibbs Richard A |
| |
| Institution: | Department of Medicinal Chemistry and Molecular Pharmacology and Center for Cancer Research, Purdue Univesity, West Lafayette, Indiana 47907, USA. |
| |
| Abstract: | Through the use of a 1,2-metalate rearrangement, six 7-substituted farnesol analogs were generated in a concise manner. This new synthetic route allowed us to quickly prepare several diverse farnesyl diphosphate analogs with interesting biological activities against mammalian protein-farnesyl transferase. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
