Rhodium-catalyzed anti-Markovnikov addition of secondary amines to arylacetylenes at room temperature |
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Authors: | Sakai Kazunori Kochi Takuya Kakiuchi Fumitoshi |
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Institution: | Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama, Kanagawa 223-8522, Japan. |
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Abstract: | An efficient method for synthesis of E-enamines by the anti-Markovnikov addition of secondary amines to terminal alkynes is described. The reaction of a variety of aryl- and heteroarylacetylenes proceeded at room temperature using a combination of a 8-quinolinolato rhodium complex and P(p-MeOC(6)H(4))(3) as a catalyst. The products were obtained as enamines by simple bulb-to-bulb distillation. |
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