Total synthesis of isofregenedadiol |
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| Authors: | Kurhade Suresh E Sanchawala Abbas I Ravikumar Velayutham Bhuniya Debnath Reddy D Srinivasa |
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| Affiliation: | Discovery Chemistry, Advinus Therapeutics Ltd., Quantum Towers, Plot No. 9, Rajiv Gandhi Infotech Park, Phase-I, Hinjewadi, Pune, 411057, India. |
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| Abstract: | The first total synthesis of isofregenedadiol, a bicyclic diterpene isolated from H. Viscosum, is reported starting from a D-(-)-pantolactone chiral pool. A one-pot quadruple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels-Alder/aromatization for the construction of a target skeleton is the highlight of the present synthesis. |
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