| APPLICATION OF HIGH PRESSURE LIQUID CHROMATOGRAPHY AND MICROSEQUENCING METHODOLOGY IN THE STRUCTURAL ANALYSIS OF HUMAN HEMOGLOBIN VARIANTS |
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| 作者姓名： | 曾溢滔 黄淑帧 A.REYNOLDS H.LAM B.B.WEBBER J.B.WILSON T.H.J.HUISMAN |
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| 作者单位： | Laboratory of Medical Genetics，Shanghai Children's Hospital，Shanghai，People's Republic of China，Laboratory of Medical Genetics，Shanghai Children's Hospital，Shanghai，People's Republic of China，Laboratory of Protein Chemistry，Comprehensive Sickle Cell Center，Department of Cell and Molecular Biology，Medical Collge of Georgia，Augusta，Ga，30912，U. S. A.，Laboratory of Protein Chemistry，Comprehensive Sickle Cell Center，Department of Cell and Molecular Biology，Medical Collge of Georgia，Augusta，Ga，30912，U. S. A.，Laboratory of Protein Chemistry，Comprehensive Sickle Cell Center，Department of Cell and Molecular Biology，Medical Collge of Georgia，Augusta，Ga，30912，U. S. A.，Laboratory of Protein Chemistry，Comprehensive Sickle Cell Center，Department of Cell and Molecular Biology，Medical Collge of Georgia，Augusta，Ga，30912，U. S. A.，Laboratory of Protein Chemistry，Comprehensive Sickle Cell Center，Department of Cell and Molecular Biology，Medical Collge of Georgia，Augusta，Ga，30912，U. S. A. |
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| 摘 要： | This paper reports the results of the analyses of 17 different Hb variants which were observed in 37 families. High pressure liquid chromatography (HPLC) was used to separate tryptic and thermolytic peptides of globin chains. The double coupling microsequencing technique can successfully be used for sequencing small or larger peptides.
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