Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism |
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| Authors: | Takizawa Toshiya Watanabe Kazuhiro Narita Koichi Oguchi Takamasa Abe Hideki Katoh Tadashi |
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| Institution: | Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan. |
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| Abstract: | The first total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, was achieved in a convergent manner; the synthesis established stereochemistry at the C5' position. |
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