Synthetic studies on bioactive natural polyketides: intramolecular nitrile oxide-olefin cycloaddition approach for construction of a macrolactone skeleton of macrosphelide B |
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Authors: | Paek Seung-Mann Suh Young-Ger |
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Institution: | College of Pharmacy, the Institute of Health Sciences, Gyeongsang National University, Jinju daero, Jinju, Gyeongnam 660-751, Korea. |
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Abstract: | Studies on the synthesis of macrosphelide B via an intramolecular nitrile oxide-olefin cycloaddition (INOC) is described. In particular, an asymmetric INOC approach using phase transfer catalysts seems to be a potentially efficient and versatile procedure for the construction of the macrolactone skeleton of macrosphelide B in terms of facial selectivity. Our preliminary and unprecedented stereoselective procedure is anticipated to be usefully applied through further studies for the synthesis of the macrosphelide family. |
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