1H,13C 2D NMR and X-ray studies of the products of the reaction between dibenzylidencyclohexanone and 6-amino-1,3-dimethyl uracil |
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Authors: | Díaz E Guzmán A Toscano R A Barrios H Corona D Fuentes A Díaz R Martinez Zuñiga E C Quintero A |
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Institution: | Instituto de Qui;mica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán D.F., 04510, México City, Mexico. maudiaz@servidor.unam.mx |
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Abstract: | The reaction of the 6-amino-1,3-dimethyl uracil with the dibenzylidencyclohexanone (1), provided three adducts whose structures result from nucleophilic attack yielding the monoadduct 3 and two isomeric bisadducts (4 and 5) in moderate yields (50-60%). The structures obtained in this study were elucidated with 2D high resolution NMR experiments, variable temperature NMR and X-ray crystallographic studies. In compound 3, the tricyclic skeleton is essentially planar and the cyclohexane ring addopts an envelope conformation. The structures 4 and 5 correspond to two isomeric spiro compounds. |
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