| Synthesis and Antibacterial Activity of 8-Substituted Phenyl-1-pyridin-3-yl-5H-bis[1,2,4]triazolo[3,4-b;4′,3′-d][1,3,4] thiadiazines |
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| 作者姓名： | Guo Qiang HU* Song Qiang XIE Wen Long HUANG Hui Bin ZHANG Medicinal College of Henan University Kaifeng China Pharmaceutical University Nanjing |
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| 作者单位： | Guo Qiang HU1*，Song Qiang XIE 1，Wen Long HUANG2，Hui Bin ZHANG2 1Medicinal College of Henan University，Kaifeng 475004 2 China Pharmaceutical University，Nanjing 210009 |
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| 摘 要： | 1,2,4-Triazole derivatives, such as 1, 2, 4-triazolo3, 4-b]thiadiazoles and 1, 2, 4- triazolo 3,4-b]thiadiazolines, as potent antibacterial agents have been widely investigated1-4. Chemically, their structures mainly focus on bi-fused heterocycles, but tri-fused derivatives have not been reported. In continuing our previous works5-8 on finding better antibacterial agents, we herein reported the synthesis and pharmacological evaluation for completely new class of compounds 4a~e with antibacte…
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