血糖控制良好的2型糖尿病患者血清VEGF—A及其受体VEGFR1和VEGFR2含量检测

研究目的：探讨血糖控制良好的2型糖尿病患者血管内皮生长因子-A（VEGF—A）及其受体VEGFR1和VEGFR2含量及其临床意义。研究方法：本文以31例血糖得到良好控制且没有明显大血管或微血管病变的2型糖尿病患者作为研究对象（实验组），30位健康志愿者为对照组，同期检测患者及健康志愿者的空腹血糖、血脂、糖化血红蛋白水平，及血清VEGF—A、VEGFR1和VEGFR2含量，并加以比较和统计学分析。重要结论：研究结果表明，血糖控制良好的2型糖尿病患者血清中的VEGF-A及其受体VEGFR1和VEGFR2的含量和健康志愿者基本一致，两者无统计学意义，这可能显示血糖水平的合理控制能延缓血管并发症的产生。同时，2型糖尿病患者的血清VEGFR2含量和高密度脂蛋白胆固醇水平之间存在负相关，而血清VEGF-A、VEGFR2含量和甘油三脂水平之间存在正相关，这也表明糖尿病患者的血脂紊乱可能参与了血管生成的调节。

A preliminary evaluation of VEGF-A,VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus

Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A （VEGF-A） and its receptors in patients with well-controlled diabetes. Methods： The study was conducted on 31 patients with well-controlled type 2 diabetes without microor macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 （VEGFR1 and VEGFR2）, fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin （HbAlc） was determined. Results： No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein （HDL）-cholesterel in the study group. Conclusions： The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.