Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii |
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| Authors: | Xu Gang Yang Xing-Wei Wu Chun-Yan Li Xiao-Nian Su Jia Deng Xu Li Yan Qin Hong-Bo Yang Li-Xin Zhao Qin-Shi |
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| Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. xugang008@mail.kib.ac.cn |
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| Abstract: | Przewalskone (1), an unprecedented adduct of two different terpenoid units via a hetero-Diels-Alder cycloaddition, was isolated from the roots of Salvia przewalskii. The structure and absolute configurations were elucidated by extensive analysis of NMR spectra and crystal X-ray diffractions. Compound 1 exhibited significant cytotoxicities against five human cancer lines in vitro (IC(50) 0.69-2.35 μM). |
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