| 用于肿瘤成像的半乳糖/酞菁近红外荧光探针 |
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| 引用本文： | 吕丰,李艳周,武莉,刘天军.用于肿瘤成像的半乳糖/酞菁近红外荧光探针[J].高等学校化学学报,2011,32(5):1010-1012. |
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| 作者姓名： | 吕丰 李艳周 武莉 刘天军 |
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| 作者单位： | 中国医学科学院北京协和医学院生物医学工程研究所天津生物医学材料重点实验室; |
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| 基金项目： | 国家“九七三”计划项目(批准号:2006CB705703); 国家重大科学研究计划项目(批准号:2006CB933202); 教育部博士学科点基金(批准号:20070023020,20101106120052)资助 |
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| 摘 要： | 本文首次报道半乳糖酞菁近红外荧光探针在肿瘤成像方面的应用。以酞菁为荧光发射基团，其在近红外区域有较高的量子产量和光学稳定性，可以解决探针的近红外光学特性；通过半乳糖对酞菁的修饰能够改善探针的溶解性和生物相容性，而且利用半乳糖的肿瘤靶向功能可以提高探针肿瘤主动靶向成像效果。结果表明它对恶性肿瘤具有高特异性结合和高灵敏度的分子探针体系，提高近红外光学分子成像效果。
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| 关 键 词： | 近红外荧光探针 半乳糖 酞菁 肿瘤成像 |
| 收稿时间： | 2010-07-19 |
Galactose Substituted Phthalocyanines for Tumor Imaging as Near-infrared Fluorescence Probe |
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| L Feng,LI Yan-Zhou,WU Li,LIU Tian-Jun.Galactose Substituted Phthalocyanines for Tumor Imaging as Near-infrared Fluorescence Probe[J].Chemical Research In Chinese Universities,2011,32(5):1010-1012. |
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| Authors: | L Feng LI Yan-Zhou WU Li LIU Tian-Jun |
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| Institution: | Lü Feng,LI Yan-Zhou,WU Li,LIU Tian-Jun(Tianjin Key Laboratory of Biomaterial Research,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China) |
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| Abstract: | Near-infrared fluorescence imaging can be used in deep tissues and organs for detecting and imaging in biological tissue.It provides effective methods of tumor detecting and tracking the diseases treatments.In order to develop tumor special probe and improve diagnose effect,phthalocyanine conjugation with galactose was synthesized as near-infrared fluorescent probes.The probe had good water-solubility and high emission ability in near-infrared region.In vivo fluorescence imaging effect and organ distributio... |
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| Keywords: | Near infrared fluorescence probe Galactose Phthalocyanines Tumor imaging |
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