Synthesis of a new class of conformationally rigid phosphino-oxazolines: highly enantioselective ligands for Ir-catalyzed asymmetric hydrogenation |
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| Authors: | Liu Duan Tang Wenjun Zhang Xumu |
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| Affiliation: | Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. |
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| Abstract: | [reaction: see text] A new class of conformationally rigid phosphino-oxazoline ligands were synthesized from readily available enantiopure phenyl glycinol. Ir complexes with these ligands are air-stable and highly enantioselective catalysts for asymmetric hydrogenation of aryl alkenes and alpha,beta-unsaturated esters in up to 99% ee. |
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