Ruthenium complexes as protein kinase inhibitors |
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Authors: | Zhang Lilu Carroll Patrick Meggers Eric |
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Affiliation: | University of Pennsylvania, Department of Chemistry, 231 S. 34th Street, Philadelphia, Pennsylvania 19104, USA. |
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Abstract: | [reaction: see text] Replacing complex natural products with simple metal complexes could lead to a new class of metallopharmaceuticals in which the metal center plays mainly a structural role. A strategy is introduced for the creation of ruthenium complex-based protein kinase inhibitors 1 (X = CO or CH(2)), morphed out of the class of indolocarbazole inhibitors with the alkaloid staurosporine as its most prominent member. |
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