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Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against <Emphasis Type="Italic">E. coli</Emphasis> |
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| Authors: | Lingling Zhang Yunhong Jiang Yulong Ding Nikolaos Daskalakis Lars Jeuken Malcolm Povey Alex J O’Neill and David W York |
| Institution: | (1) School of Civil and Environmental Engineering, University of Science and Technology, Beijing, China;(2) Institute of Particle Science & Engineering, University of Leeds, Leeds, UK;(3) School of Physics and Astronomy, University of Leeds, Leeds, UK;(4) Procter Department of Food Science, University of Leeds, Leeds, UK;(5) Faculty of Biological Sciences, University of Leeds, Leeds, UK;(6) Procter and Gamble Newcastle Technical Centre, Newcastle-upon-Tyne, UK; |
| Abstract: | Aqueous suspensions containing 4.45 × 10−5 − 1.25 × 10−3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactions between other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the conditions of this study. |
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