Synthesis, conformation, and stereodynamics of a salt of 2-{[2-(3,4-dichlorophenyl)- ethyl]propylamino}-1-pyridin-3-ylethanol |
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| Authors: | Korosec Tina Grdadolnik Joze Urleb Uros Kocjan Darko Grdadolnik Simona Golic |
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| Affiliation: | Drug Discovery, Lek Pharmaceuticals d. d., Verovskova 57, SI-1526 Ljubljana, Slovenia. |
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| Abstract: | [reaction: see text] A novel synthetic route was developed for 2-{[2-(3,4-dichlorophenyl)ethyl]propylamino}-1-pyridin-3-ylethanol (4). A dynamic process due to nitrogen inversion at the central amine nitrogen has been identified by NMR spectroscopy for the dihydrobromide salt of this compound. The conformational properties of the diastereomeric pair were determined by analysis of NOE connectivities and MO calculations. |
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