Liquid chromatographic resolution of gemifloxacin mesylate on a chiral stationary phase derived from crown ether |
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Authors: | Hyun Myung Ho Han Sang Cheol Cho Yoon Jae Jin Jong Sung Lee Wonjae |
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Institution: | Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Pusan 609-735, Korea. mhhyun@pusan.ac.kr |
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Abstract: | A new racemic fluoroquinolone antibacterial agent, gemifloxacin mesylate, has been successfully resolved on a chiral stationary phase (CSP) derived from (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid. Compared to the Crownpak CR(+) column, the CSP used in this study was more effective for the resolution of racemic gemifloxacin mesylate, especially in terms of analytical time. The resolution of gemifloxacin mesylate enantiomers on the CSP was found to be dependent on the type and content of organic and acidic modifiers in the aqueous mobile phase and the column temperature. |
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