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Effects of the ancillary ligands of polypyridyl ruthenium(II) complexes on the DNA-binding and photocleavage behaviors |
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| Authors: | Li-Feng Tan Hui Chao Kang-Cheng Zhen Jun-Jie Fei Fang Wang Yang-Fan Zhou Liang-Nian Ji |
| Affiliation: | aCollege of Chemistry, Xiangtan University, Xiangtan 411105, PR China bDepartment of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China |
| Abstract: | The new polypyridyl ligand MIP {MIP = 2-(2,3-methylenedioxyphenyl)imidazo[4,5-f]1,10-phenanthroline} and its ruthenium(II) complexes [Ru(phen)2(MIP)]2+ (1) (phen = 1,10-phenanthroline) and [Ru(dmp)2(MIP)]2+ (2) (dmp = 2,9-dimethyl-1,10-phenanthroline) were synthesized and characterized by elemental analysis, MS and 1H NMR spectroscopy. The DNA-binding properties of the two complexes to calf-thymus DNA (CT-DNA) were investigated by different spectrophotometric methods and viscosity measurements, as well as equilibrium dialysis and circular dichroism spectroscopy. The results suggest that complex 1 binds to CT-DNA through intercalation, and complex 2 binds to CT-DNA via a partial intercalative mode. This difference in binding mode probably is caused by the different ancillary ligands. Also, when irradiated at 400 nm, complex 1 was found to be a more-effective DNA-cleaving agent than complex 2. |
| Keywords: | Ruthenium(II) complex Polypyridyl ligand DNA-binding Photocleavage |
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