一种简易合成具有近红外吸收的纳米金壳球体方法

对经典的合成方法进行了详细的系统性的研究，通过改变合成过程中各反应物的参数，简易地得到了稳定的具有近红外吸收的纳米金壳球体。利用紫外可见光谱、动态光散射仪和透射电镜研究了制备过程中的各个参数对纳米金壳球体光学性质的影响。实验结果显示胺化试剂的用量以及先导试剂的预处理等在制备过程中都是重要影响因素。由改进方法所制备的纳米金壳球体具有很窄的粒径分布，并能在没有外加表面活性剂的条件下稳定地单分散于水溶液中。这些方法的改进提供了一种简易制备具有近红外吸收的纳米金壳球体的方法，从而有利于拓展此类纳米粒子在生物医学领域中的应用研究

A Facile Approach to the Synthesis of Gold Nanoshells with Near Infrared Responsive Properties

A very detailed study of the most important parameters that involved in the preparation of gold nanoshells with near infrared (NIR) absorption properties is reported. The importance of this work lies in the deep understanding of how each parameter contributes to the formation of gold nanoshells in terms of size, shell thickness, optical property and particle stability, which have not been emphasized in the literatures. Through detailed characterization by UV‐Vis spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis, a facile approach to synthesize nanoshells with optimal optical properties in the NIR region was obtained. The amount of reagents, the ratio and condition of reagents, the reaction time, all played important roles in the formation of stable, narrow‐size distributed gold nanoshells with NIR absorption properties, which have significant applications to photothermal therapy of cancers in biomedical area.