Thermoanalytical,FTIR and X-ray studies of gemfibrozil-cyclodextrin complexes |
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| Authors: | Z Aigner H B Hassan O Berkesi M Kata I Erős |
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| Institution: | (1) Department of Pharmaceutical Technology, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary;(2) Department of Pharmaceutical Technology, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary;(3) Department of Physical Chemistry, University of Szeged, 6720 Szeged, Rerrich Béla tér 1, Hungary;(4) Department of Pharmaceutical Technology, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary;(5) Department of Pharmaceutical Technology, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary |
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| Abstract: | Summary Inclusion complexation between dimethyl-β-cyclodextrin and a very poorly water-soluble serum lipid-regulating agent, gemfibrozil, was studied. Products were prepared by several methods (physical mixing, kneading, spray-drying and ultrasonic treatment) in four different molecular ratios (2:1, 1:1, 1:2 and 1:3). The possibility of complex formation between the drug and the host molecule was studied by thermal analysis. Supplementary techniques, such as Fourier transformation-infrared spectroscopy and X-ray diffractometry, were also applied to interpret the results of thermal study of the products. |
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| Keywords: | DSC X-ray diffractometry FTIR spectroscopy dimethyl- ? -cyclodextrin gemfibrozil |
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