Stereochemistry of cytidine: conformational analysis and hydrogen bonding |
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| Authors: | Sungzong Kang |
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| Affiliation: | Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York, N.Y. 10029 U.S.A. |
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| Abstract: | The energy calculations using the INDO molecular orbital method and classical potential function show that the syn conformation of pyrimidine nucleosides having the C(2')-endo or C(2')-endo-C(3')-endo sugar ring puckering is as stable as the corresponding anti form.The O(2')-O(2') base-ribose hydrogen bonding significantly alters the ΦCN conformation by confining the allowed ΦCN ranges to about 150–210°. |
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