Artificial peptide-nanospheres self-assembled from three-way junctions of beta-sheet-forming peptides |
| |
Authors: | Matsuura Kazunori Murasato Kazuya Kimizuka Nobuo |
| |
Affiliation: | Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan. ma14tcm@mbox.nc.kyushu-u.ac.jp |
| |
Abstract: | Rational design of self-assembly of proteins, which plays pivotal roles in biology, is an important subject for biotechnology and also bottom-up nanotechnology. This paper has proposed a novel strategy for construction of artificial peptide-nanospheres by self-assembly. Mimicking formation of spherical viruses and clathrin, we designed a novel C3-symmetric peptide conjugate bearing three beta-sheet-forming peptides. These peptide conjugates formed antiparallel beta-structures and self-assembled into nanospheres with the size of about 20 nm in the acidic solution. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|