Three-component coupling reaction and cyclization of N-tosylimines and TMS-substituted propiolate mediated by DABCO |
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Authors: | Matsuya Yuji Hayashi Kousuke Wada Akiho Nemoto Hideo |
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Institution: | Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. |
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Abstract: | A new three-component coupling reaction of methyl 3-trimethylsilylpropiolate, N-tosylimine, and tosylamide mediated by DABCO was developed. This reaction was based on the consecutive alpha- and beta-activation method of propiolate involving intramolecular silyl migration previously developed by our group. On the basis of these results, a new cyclization reaction was designed to find a chromene-forming reaction utilizing salicyl N-tosylimine as a bifunctional substrate. |
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