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UV-curable low-surface-energy fluorinated poly(urethane-acrylate)s for biomedical applications |
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| Authors: | YH Lin NK Chou SH Chu KH Hsieh |
| Institution: | a Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan b Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan c Department of Surgery, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan d Department of Cardiovascular Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan |
| Abstract: | Novel UV-curable fluorinated poly(urethane-acrylate) (FPUA) oligomers have been synthesized from 1H,1H,12H,12H-perfluoro-1,12-dodecanediol (PFDDOL), either 1,6-hexamethylene diisocyanate (HDI) or 4,4′-diphenylmethane diisocyanate (MDI), and 2-hydroxyethyl methacrylate (HEMA) for end-capping with photo-crosslinkable methacrylate groups. The fluorine content and the nature of the isocyanate were investigated to determine their effects on the physical properties, surface properties, and blood compatibilities of the polymers. The introduction of hydrophobic fluorocarbon chains led to phase separation and a low total surface energy, which reduced the adhesion of blood platelets onto the materials. The HDI-type UV-curable, fluorinated poly(urethane-acrylate) exhibited a low-surface-energy and superior blood compatibility (as determined from RIPA values). |
| Keywords: | UV-curable Low-surface-energy Fluorinated Poly(urethane-acrylate) Phase separation Blood compatibility |
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