Synthesis and characterization of original 2-(dimethylamino)ethyl methacrylate/poly(ethyleneglycol) star-copolymers |
| |
Authors: | Yong-Ho Shim Olivier Coulembier Philippe Dubois |
| |
Affiliation: | a Laboratory of Polymeric and Composite Materials, Center of Innovation and Research in Materials and Polymers (CIRMAP), University of Mons-Hainaut, Place du Parc 20, B-7000 Mons, Belgium b Laboratory for Chemistry of Novel Materials, Center of Innovation and Research in Materials and Polymers (CIRMAP), University of Mons-Hainaut, Place du Parc 20, B-7000 Mons, Belgium |
| |
Abstract: | Novel synthetic transfection vectors with linear triblock and star-shaped diblock copolymer architectures have been synthesized by atom transfer radical polymerization (ATRP). Based on 2-(dimethylamino)ethyl methacrylate (DMAEMA) and copolymerization with poly(ethyleneglycol) α-methoxy, ω-methacrylate (MAPEG), the synthesis was realized using CuBr ligated with 1,1,4,7,10,10-hexamethyltriethylenetetramine (HMTETA) as catalytic complex and either ethyl 2-bromoisobutyrate (EBiB) or bis(α-bromoisobutyryl) N-methyl diethanolamine (DEA) or tris(α-bromoisobutyryl) triethanolamine (TEA) as (multifunctional)initiator. The polymers were characterized by GPC and NMR. The solution properties of these homopolymers and palm-tree-like copolymers were investigated by viscometry either in pure water or in buffered aqueous solutions. Interestingly, all the synthesized polymers show polyelectrolyte effect in Millipore water (25 °C) and in Hepes (20 mM) buffer solution (pH 7.4, NaCl 155 mM, 25 °C). Fitting of these viscometric data according to either Fuoss or Fedors equation allows for calculating the intrinsic viscosity of the polymers. These results are compared with dynamic light scattering (DLS) experiments to determine absolute masses. Finally, DEA based palm-tree-like copolymer is investigated to AFM measurement and micelles were observed at pH 8. |
| |
Keywords: | 2-(Dimethylamino)ethyl methacrylate Star-shaped polymer ATRP Viscometry DLS AFM |
本文献已被 ScienceDirect 等数据库收录! |
|