Synthesis of polypeptide/inorganic hybrid block copolymers |
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Authors: | Xuewei Zhang Jean-Jacques Robin |
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Affiliation: | Institut Charles Gerhardt Montpellier UMR5253 CNRS-UM2-ENSCM-UM1, Equipe Ingénierie et Architectures Macromoléculaires, Université Montpellier II cc1702, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France |
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Abstract: | Polypeptide/inorganic hybrid copolymers were obtained by a four-step synthetic approach combining (i) atom transfer polymerization of tert-butyl acrylate, (ii) chemical modification of the bromo end groups of ATRP-polymers into primary amino group using Gabriel reaction, (iii) ring opening polymerization of Nε-trifluoroacetyl-l-lysine or γ-benzyl-l-glutamate N-carboxyanhydrides followed by (iv) the transamidification reaction using a large excess of (3-aminopropyl)trimethoxysilane to substitute the tert-butyl groups of the poly(tert-butyl acrylate) block. Products were characterized using 1H NMR, FT-IR, DSC and MALDI-TOF MS. These techniques proved that polymerization of tert-butyl acrylate was controlled whatever the molecular weight targeted and that bromide was quantitatively converted to amino end group by a original method leading to the synthesis of copolymers in the presence of N-carboxyanhydrides as monomers. Amphiphilic polypeptide/inorganic hybrid copolymers were then achieved. |
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Keywords: | Block copolymers Hybrid materials Organic-inorganic hybrid polymer Polymer synthesis |
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