In situ photopolymerization-coated pellets for pH-dependent drug delivery |
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Authors: | Marcos Mayo-Pedrosa Ramon Martinez-Pacheco Angel Concheiro |
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Institution: | Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782- Santiago de Compostela, Spain |
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Abstract: | An in situ photopolymerization-coating technique was applied to wrap the pellets surface with a pH-sensitive hydrogel layer made from acrylic acid and hydrophobic acrylate monomers. Powdered cellulose (Elcema® P100) and poly(vinylpyrrolidone) (Kollidon® 30) pellets containing theophylline were prepared by extrusion-spheronization, sprayed with an ethanol:water 50:50 v/v solution of the monomers, the cross-linker (N,N′-methylenebis(acrylamide)) and the initiator (Irgacure® 2959), and immediately irradiated at 366 nm. The composition of coating mixture and the time of irradiation were optimized using oscillatory rheometry and analyzing the swelling and the drug release behaviour of the resultant hydrogels. When acrylic acid:lauryl acrylate 88:12 molar ratio was used, the coating did not significantly change the shape, size, or friability of the pellets, but remarkably modified theophylline release profiles. The thicker the coating layer, the better the pH-dependent control of drug release. |
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Keywords: | pH-responsive hydrogel Coating Extrusion-spheronization Modified oral drug delivery pH-dependent delivery |
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