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In vitro anti-oxidant potential of new metabolites from Hypericum oblongifolium (Guttiferae) |
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| Authors: | Naila Raziq Muhammad Shaiq Ali Salman Zafar Muhammad Imran Ali |
| Institution: | 1. Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan;2. Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan;3. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan;4. Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan;5. Govt. Degree Boys College, Nishtar Road, Karachi, Pakistan |
| Abstract: | Phytochemical investigations on Hypericum oblongifolium led to the isolation of a flavone named folicitin (1) and a bicyclic conjugated lactone, folenolide (2) from the ethyl acetate fraction of methanolic extract. Both metabolites were characterised as new compounds based on detailed spectroscopic analyses. In vitro anti-oxidant potential of both the compounds was evaluated by the DPPH radical scavenging assay. Compound 1 exhibited significant antioxidant activity while compound 2 was found inactive. |
| Keywords: | Hypericum oblongifolium Guttiferae folicitin folenolide flavone antioxidant |