Two new eunicellin diterpenoids from the South China Sea gorgonian Muricella sibogae and their bioactivities |
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| Authors: | Xing-Wang Zhang Xu-Li Tang Hong-Rui Yuan Dan-Qing Feng Pei Su |
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| Affiliation: | 1. Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Chinese Ministry of Education, 5 Yushan Road, Qingdao266003, Shandong, P.R. China;2. College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, P.R. China;3. College of Ocean and Earth Sciences, Xiamen University, Xiamen, P.R. China |
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| Abstract: | A systematic re-study on gorgonian Muricella sibogae from South China Sea yielded 10 eunicellin-based diterpenoids including two new ones, sibogins C and D (1 and 2). Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, IR and MS) and by comparison with data reported in literatures. All the isolates were tested for cytotoxic and antifouling activities. Compounds 3 and 5 showed significant antifouling activity against the green mussel Perna viridis, and especially 3 was suggested as a potent low-toxic antifouling agent with a large LC50/EC50 value of 18.6. This was the first report on the antifouling activity of the eunicellin-type diterpenoids against the green mussel. |
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| Keywords: | gorgonian Muricella sibogae eunicellin-based diterpenoids cytotoxicity antifouling activity |
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