Contraceptive studies of isolated fractions of Cuminum cyminum in male albino rats |
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Authors: | Poonam Saxena Rajnish Gupta |
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Institution: | Department of Zoology, Reproductive Physiology Section, Centre for Advanced Studies, University of Rajasthan, Jaipur 302 004, India |
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Abstract: | The contraceptive efficacy of Cuminum cyminum isolated fractions (CcFr) in male albino rats was investigated. Oral dose of CcFr at 50 mg/rat/day for 60 days revealed no significant changes in body weight, while marked abnormalities in spermatogenesis were observed with decreased counts (P ≤ 0.001) in round spermatids, preleptotene spermatocytes and secondary spermatocytes. Cross sectional surface area of Sertoli cells as well as number of mature Leydig cell were decreased significantly (P ≤ 0.001). Testicular as well as accessory sex organ biochemical parameters were significantly changed (P ≤ 0.001). Sperm motility, density and morphology were resulted in 100% negative fertility. Testosterone levels were declined significantly. In conclusion, Cuminum cyminum inhibited spermatogenesis in rats, indicating the possibility of developing an herbal male contraceptive. |
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Keywords: | spermatogenesis sperm morphology sertoli cells leydig cells testosterone |
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