A new picrotoxane sesquiterpene from the berries of Baccaurea ramiflora with antifungal activity against Colletotrichum gloeosporioides |
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| Authors: | Zheng-Hong Pan De-Sheng Ning Si-Si Huang Yun-Fei Wu Tao Ding Lei Luo |
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| Affiliation: | 1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, P.R. China;2. Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, P.R. China |
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| Abstract: | Three picrotoxane sesquiterpenes including one new glycoside and two known constituents, sapidolide A (2) and picrotoximaesin (3), were isolated from the berries of Baccaurea ramiflora. The structure of the new sesquiterpene glycoside, ramifloside (1), was elucidated as 2-one-6α-hydroxy-13-nor-11-picrotoxen-3(15β)-olide 10-O-β-d-glucopyranoside on the basis of extensive spectroscopic analysis. Compounds 1–3 exhibited antifungal activity against Colletotrichum gloeosporioides with MICs of 12.5, 12.5 and 50 μg/mL. |
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| Keywords: | Baccaurea ramiflora picrotoxane sesquiterpene glycoside antifungal activity ramifloside |
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