Hyrtioseragamines A and B, new alkaloids from the sponge Hyrtios species |
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| Authors: | Takahashi Yohei Iinuma Yoshiro Kubota Takaaki Tsuda Masashi Sekiguchi Mitsuhiro Mikami Yuzuru Fromont Jane Kobayashi Jun'ichi |
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| Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. |
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| Abstract: | Two novel alkaloids with a furo2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo2,3-b]pyrazine-related moiety. |
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