Trifunctionalization of the purine scaffold using Mg and Zn organometallic intermediates |
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| Authors: | Zimdars Silvia Mollat du Jourdin Xavier Crestey François Carell Thomas Knochel Paul |
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| Affiliation: | Department Chemie & Biochemie, Ludwig-Maximilians-Universit?t München, Butenandtstrasse 5-13, 81377 München, Germany. |
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| Abstract: | Starting from an appropriate 6-chloro-2-TMS-purine derivative, a regioselective functionalization of the purine scaffold was achieved successively at positions 8, 6, and 2 via zinc and magnesium intermediates which were generated either by a direct zincation with TMPZnCl·LiCl or by an I/Mg exchange with iPrMgCl. |
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