Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp |
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| Authors: | Oh Dong-Chan Poulsen Michael Currie Cameron R Clardy Jon |
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| Affiliation: | Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. |
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| Abstract: | A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM). |
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