Enhanced two-photon singlet oxygen generation by photosensitizer-doped conjugated polymer nanoparticles |
| |
Authors: | Shen Xiaoqin He Fang Wu Jihong Xu Guo Qin Yao Shao Q Xu Qing-Hua |
| |
Affiliation: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543. |
| |
Abstract: | We have prepared photosensitizer-doped conjugated polymer nanoparticles by using a reprecipitation method. The conjugated polymer, poly[9,9-dibromohexylfluorene-2,7-ylenethylene-alt-1,4-(2,5-dimethoxy)phenylene] (PFEMO), was used as the host matrix to disperse tetraphenylporphyrin (TPP). These TPP-doped PFEMO nanoparticles are stable and have a uniform size of ~50 nm. Efficient intraparticle energy transfer from PFEMO to TPP has been observed. The TPP emission of the nanoparticles was found to be enhanced by 21-fold by PFEMO under two-photon excitation. Enhanced two-photon excitation singlet oxygen generation efficiency in the TPP-doped PFEMO nanoparticles has been demonstrated. Our results suggest that these photosensitizer-doped conjugated polymer nanoparticles can act as novel photosensitizing agents for two-photon photodynamic therapy and related applications. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|