Nanomechanical stimulus accelerates and directs the self-assembly of silk-elastin-like nanofibers |
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Authors: | Chang Jonathan Peng Xiu-Feng Hijji Karam Cappello Joseph Ghandehari Hamidreza Solares Santiago D Seog Joonil |
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Institution: | Department of Materials Science and Engineering, University of Maryland, College Park, Maryland 20742, United States. |
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Abstract: | One-dimensional nanostructures are ideal building blocks for functional nanoscale assembly. Peptide-based nanofibers have great potential in building smart hierarchical structures due to their tunable structures at the single residue level and their ability to reconfigure themselves in response to environmental stimuli. We observed that pre-adsorbed silk-elastin-based protein polymers self-assemble into nanofibers through conformational changes on a mica substrate. Furthermore, we demonstrate that the rate of self-assembly was significantly enhanced by applying a nanomechanical stimulus using atomic force microscopy. The orientation of the newly grown nanofibers was mostly perpendicular to the scanning direction, implying that the new fiber assembly was locally activated with directional control. Our method provides a novel way to prepare nanofiber patterned substrates using a bottom-up approach. |
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